Together with our data showing abnormal actin cytoskeleton in hTERT-RPE1 cells and in the photoreceptors of RPGR KO mice (Figure 1 and 2), this suggests a role of the RPGR protein complex in regulating the actin cytoskeleton, which may underlie the pathogenesis involved in retinal ciliopathies [57]. This evidence concerns the gene RPGR and retinal ciliopathy.