Expression of c-FLIP was reduced by knockdown of HIF2-alpha in three dormant-like/starvation-resistant RCC cell lines (Figure 4A–4C), whereas knockdown of c-FLIP (siFLIP) induced apoptotic cell death more rapidly and effectively than knockdown of HIF2-alpha in starvation-resistant RCC (Figures 4D and 5A). This evidence concerns the gene EPAS1 and renal cell carcinoma.