As shown in Figure 10, EGFR/HER3 depletion in HCC-1143 cells induced senescence by β-gal staining (Figure 10A, p < 0.001), p15INK4b expression and apoptosis by caspase-3 activation (Figure 10B) compared to control and cytokine alone treated cells. Here, CDKN2B is linked to hepatocellular carcinoma.