RAI2 and colorectal carcinoma: The levels of RAI2 expression were significantly lower in CRC samples compared to adjacent normal colorectal mucosa samples (P < 0.0001, Fig. 2e), while no association was found between RAI2 mRNA expression and 5-year OS (n = 333, P = 0.3168, Fig. 2f) or 5-year RFS (n = 341, P = 0.0951, Fig. 2f) in this cohort.