In B16F10 and Clone M3 mouse melanoma cells, administration of cinnamon extract for 24 h markedly downregulated the expression level of both Cox-2 and HIF-1α in a concentration-dependent (0.1, 0.2, 0.3, 0.4, and 0.5 mg/ml) pattern, with complete restriction of expression of Cox-2 at 0.5 mg/ml of CE [12]. This evidence concerns the gene PTGS2 and melanoma.