Additional studies are required to determine the contribution of OVA-specific IgG in this model system and whether IgG anti-IgE/IgE immune complexes serve additional tolerogenic roles in the context of asthma or allergen-specific immunotherapy, which may include effects on regulatory cells [12] and co-engagement of FcεRI with FcγRIIb [13]. The gene discussed is IGHE; the disease is asthma.