To test whether inhibition of LDHA with the inhibitor gossypol would prevent bleomycin-induced pulmonary fibrosis, mice were exposed to bleomycin or saline by oropharyngeal aspiration (OA), and subsequently dosed with 5, 10, or 20 mg/kg gossypol or vehicle via daily sub-cutaneous injection starting the day of bleomycin administration (Fig 2A). The gene discussed is LDHA; the disease is pulmonary fibrosis.