Regardless of the etiology, the activation of the innate immune system via Toll-Like receptor-4 (TLR4) signaling pathway through exogenous ligands such as e.g. bacterial lipopolysaccharides (LPS) and endogenous damage associated ligands stays at the center of many liver inflammatory diseases such as e.g. nonalcoholic (NASH) and alcoholic (ASH) steatohepatitis, oxidative drug toxicity, hepatic immune disorders, and liver allograft rejection [4]. Here, TLR4 is linked to liver disorder.