Similarly, CTGF, an important pro-fibrogenic modulator of liver fibrosis, increased after 4h and 20h in HSC cultured in an inflammatory environment whereas treatment with conditioned medium from LPS + UDCA-LPE treated RAW264.7 cells resulted in very limited and significantly lower CTGF expression and protein levels (Fig 5C and 5D). The gene discussed is CCN2; the disease is Hepatic fibrosis.