F10 and deep vein thrombosis: This systematic review and meta-analysis provides an updated and pooled analysis of efficacy and safety outcomes related to the use of FDA-approved DOACs (the direct thrombin inhibitor dabigatran and the factor Xa inhibitors apixaban, rivaroxaban, and edoxaban), in comparison with Vitamin K-antagonist-based therapies, for thromboembolic stroke prophylaxis in patients with NVAF and in treatment of patients with acute VTE (DVT with or without PE).