We confirmed this finding using the larger non-AJ Crohn’s disease ImmunoChip dataset to provide a more precise estimate of the 1-hit effect (OR = 2.17; 95% confidence interval [2.07, 2.27], S4 Table) and the non-additive 2-hit effects in NOD2 (OR = 9.93; 95% confidence interval [8.88, 11.13], S5 Table). This evidence concerns the gene NOD2 and Crohn disease.