Clinical studies focused on type 2 diabetes (T2D), have shown a positive correlation between circulating vitD levels and insulin sensitivity, indicating that vitD deficiency may predispose to glucose intolerance, the secretion of altered insulin and T2D8–10, either through a direct action via activation of the vitamin D receptor (VDR), or indirectly through calcemic hormones and also through inflammatory processes1,11,12. This evidence concerns the gene INS and Glucose intolerance.