As for hepatic BMAL1 recruitment, administration of HF diet with ROSI reversed the HF diet-induced BMAL1 binding to target E boxes in SC WAT (Fig. 4e), suggesting that a key mechanism by which diet controls peripheral BMAL1 function similarly in adipose tissue, muscle, and liver is through feeding-induced changes in insulin sensitivity. Here, BMAL1 is linked to hydrops fetalis.