For example, the kinases AKT2 and GSK3β have been reported to alter BMAL1 activity [18–21], and small molecule inhibitors of GSK3β induce a phase advance of the clock, as measured by Per2 promoter-driven gene expression [22], similar to the hepatic phase advance that occurs under HF diet [17, 23]. This evidence concerns the gene PER2 and hydrops fetalis.