While HF did not significantly change the overall abundance of chromatin localized BMAL1 (Fig. 1f, g), BMAL1 target genes, Dbp, Chrono (Gm129), and Fabp2 were induced under HF feeding at ZT4 (Fig. 2b), and Bmal1 mRNA itself, which reaches its nadir during the rest phase, was depressed at ZT4 but elevated at ZT16. The gene discussed is BMAL1; the disease is hydrops fetalis.