To further determine whether ROSI treatment had direct effects on the liver, we analyzed the expression of Pparγ and some of its direct target genes, Cidec and Pcx. Cidec and Pcx expression was induced by ROSI in chow-fed and HF mice (Fig. 3e), most notably under HF diet due to the increase in diurnal PPARγ expression (Fig. 1e and S1J). Here, PPARG is linked to hydrops fetalis.