TNF and neoplasm: Our results show that cytotoxic dose TNFα induces apoptosis through activation of BAD-mediated mitochondrial death pathway, in which the executioner apoptotic caspases are the known targets of NF-κB-induced inhibitors of apoptosis (IAPs).75 Indeed, when pre-treated with non-cytotoxic dose TNFα, which induces NF-κB activation without apoptosis, the cells were protected from cytotoxic dose TNFα-induced apoptosis.75 Cells with constitutive activation of NF-κB, such as many tumor cells and some cultured cells, will be resistant to cytotoxic dose TNFα-induced apoptosis.