Under conditions of CLP-induced high-grade sepsis, WT littermates but not Bad−/− mice had significantly increased serum concentrations of several tissue damage markers including ALT (liver), AST (liver, heart and muscle), BUN (kidney), and LDH (lung and general cellular damage) (Fig. 5d), suggesting that loss of Bad protects organs from tissue damage in septic shock. Here, BAD is linked to Sepsis.