To determine that BAD pro-apoptotic activity is involved in polymicrobial infection-induced cell death, tissue damage of multiple organs and mortality in septic shock, we used Bad−/− mice that have been reconstituted through adenoviral vector encoding WT Bad [Bad(WT)+], the phospho-mimetic Bad(S26D) mutant [Bad(S26D)+] (Fig. 2c), or the non-phosphorylatable Bad(S26A) mutant [Bad(S26A)+] (Fig. 2d). Here, BAD is linked to infection.