EIF4EBP1 and hyperinsulinemic hypoglycemia, familial, 4: Another possibility is that leucine and its effects on mTORC1/4EBP1 could selectively promote translation of a subset of mRNAs (e.g TOP-mRNAs), with leucine deficiency resulting in reduced translation of one or more members of this subset to effect changes in gene expression that indirectly mediate a more global suppression of mRNA translation51–53.