The findings that 10e treatment of HL-60 cells decreases the levels of c-Flip, Mcl-1, HDAC3, and HDAC6, while increasing the level of Noxa was found to be true in additional AML cell lines, such as THP-1, MOLM-13, NB4, U937, and KG-1 (Fig. 3). Here, CFLAR is linked to acute myeloid leukemia.