FAM188B mRNA expression was highly increased in multiple CRC datasets (TCGA colorectal 2, p = 2.48 × 10−16; GSE20916, p = 6.59 × 10−7; GSE20842, p = 2.68 × 10−26) from Oncomine database21 (Fig. 1d). This evidence concerns the gene MINDY4 and colorectal carcinoma.