EGFR and neoplasm: Since it has been demonstrated that many tumor cells which overexpress EGFR, including the MDA-MB-468 cells, have limited ligand-stimulated EGFR degradation44 and that tyrosine dephosphorylation of EGFR is correlated with an increased EGFR stability37, we wanted to know where the EGFR accumulated after MβCD treatment, in order to completely understand how signaling by the EGFR is terminated.