Importantly, neither the strongest common T2D-associated variant of TCF7L2 rs790314611 nor the previously reported T2D-associated variant rs7903146 in DPS10 modified the association of IPA levels and insulin secretion, confirming that the effect of TCF7L2 is probably not mediated by IPA. The gene discussed is TCF7L2; the disease is type 2 diabetes mellitus.