Furthermore, knocking down DNMT1, using 2 different siRNAs (siDNMT1-1# and siDNMT1-2#), in LMP1-expressing NPC cells rescued PTEN expression and suppression of AKT pathway (Fig. 2k, l, Supplementary Figure 1), and hampered aerobic glycolysis to a degree similar to that observed in LMP1-negative CNE1 cells (Fig. 2m, n). This evidence concerns the gene PTEN and nasopharyngeal carcinoma.