KDR and neoplasm: Hence, sVEGFR1 was found to promote adhesion and migration of endothelial cells through interaction with α5β1 integrin and activation of VEGFR2 signalling, thus acting rather as a pro-angiogenic molecule.14,15 In addition, sVEGFR1 was reported to trigger non-apoptotic cell death in ovarian and colorectal cancer cell lines, indicating that sVEGFR1 could also inhibit tumour growth directly.16 However, the characterisation, if they exist, of specific functions associated with sVEGFR1 splice variants remain poorly understood in cancer cells, notably during the response to therapies.