The fact that several L2 markers are independently known as breast cancer-associated antigens such as SYTL2 and ANKRD30A40, and that it shows highest expression of CDKN1B/p27 as a marker for potential breast cancer cells of origin31 further corroborates the link between the hormone-responsive L2 cell type to breast cancer in general. This evidence concerns the gene SYTL2 and breast cancer.