APOE and Alzheimer disease: Our results revealed that the eQTL may influence the progression of AD APOE ε4 carriers by increasing the expression level of APOE. -491A/T, or rs449647, a polymorphism located in APOE transcriptional regulatory region, is the earliestly-reported APOE expression-associated variant by luciferase/β-galactosidase activity assay related to AD independent of APOE ε4 dosage33.