HDAC2 and Alzheimer disease: rs483082, a brain eQTL for APOE which is in complete linkage with rs438811 and was also identified can interact with APOE ε4 status to confer AD risk in this study, was the target of multiple transcription factors: HNF4G, CEBPB, MXI1, HDAC2, SP1, RFX5, MAX, EP300, JUND, FOSL2, ZBTB7A and CEBPD.