These evidences which could explain the AD pathogenic nature of APOE4 include: APOE4 impairs synaptic repair and plasticity4,5; might be less efficient in transporting brain cholesterol6,7; increases Aβ aggregation and impairs clearance8,9; increases formation of neurofibrillary tangles10; decreases metabolic activity of neurons11. Here, APOE is linked to Alzheimer disease.