APOE and Alzheimer disease: We used multivariate logistic regression analysis to identify eQTLs which can confer AD risk in the 34 proxy eQTLs for APOE. After adjustment for age and gender, substantia nigra eQTL rs438811 (odds ratio [OR], 2.343; 95% confidence interval [CI], 2.205–2.490; raw P-value = 7.49 × 10−167) was associated with AD (Table 2).