Sub-group analysis showed rs438811 confer risk predominantly in APOE ε4 carriers (OR, 1.267; 95% CI, 1.124–1.430; P-value = 1.12 × 10−4; Table 3), which indicates carrying one minor allele T of rs438811 can increase the opportunity of developing to AD by 26.75% in APOE ε4 carriers. The gene discussed is APOE; the disease is Alzheimer disease.