While many other SNPs were also associated with incident MetS, the ones that had p ≤ 0.01 were among women, including MEGALIN SNP rs830966: G allele, HR = 4.28, 95% CI:1.80–10.20) and 6 protective VDR SNPs located near a well-studied SNP names Cdx-I, rs11568250, whose C allele was also inversely related to incident MetS among women (HR = 0.11, 95%CI: 0.02–0.47, p = 0.003). Here, LRP2 is linked to metabolic syndrome.