At higher concentrations (in the sub-micromolar range), TBE-31 suppresses non-small cell lung cancer (NSCLC) cell migration and epithelial mesenchymal transition (EMT) by inhibiting TGFβ-dependent actin stress fiber formation and by directly binding to actin, inhibiting its polymerization26, suggesting the potential utility of TBE-31 in metastatic disease. Here, TGFB1 is linked to non-small cell lung carcinoma.