ATG12 and neoplasm: Mechanistically, metformin increases miR-570-3p by the demethylation of DNA, and the increase of miR-570-3p repressed the translation of its target, lung cancer metastasis-related protein (LCMR1), which has an important role in tumor metastasis, and another target, autophagy-related gene 12 (ATG12), which is an autophagy marker that is significant for the resistance to apoptosis in many types of tumors.