Notably, we selected analytes that demonstrate elevated expression in TB patients compared to household contacts or controls, classify disease severity or susceptibility in preclinical models of infection, or are elevated in cases of recurrence, including: CXCL5 (ENA-78) [32,33], GM-CSF [34,35], IL-1β [28,36], IL-2 [32,35], IL-2RA [37,38], IL-5 [39], IL-6 [28,40,41], IL-9, IL-12p70 [42], IL-13 [35], IL-15/15R [43], IP-10 (CXCL-10) [35,40,43], MCP-1 [43], MIP1-β [35], and TNFα [36,37,40]. The gene discussed is IL6; the disease is tuberculosis.