TGF-β [5,6,7,8,10,72], PAR2 [67,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89] and PAR1 [78,86,87,90,91] have been implicated in driving proliferation, EMT, cell migration, invasion, and metastasis of cancer cells. This evidence concerns the gene MARK2 and cancer.