Thus, the IL-8 signal might contribute to tumor progression and characteristic fibrosis in pancreatic cancer by inducing neo-angiogenesis through activation of the vascular endothelial growth (VEGF) factor pathway and enhancement of the activity of MMP2 and MMP9, which in turn increases the metastatic activity of the underlying malignancy [95]. The gene discussed is CXCL8; the disease is familial pancreatic carcinoma.