The complexity of melanoma is also conferred by the myriad of signaling pathways involved in melanoma development, pathways that coincide with the ones required for melanocytes development, like: Notch, Wnt, endothelins, SOX (sex-determining region Y–like–SRY high-mobility group—HMG box) proteins, mitogen-activated protein kinase (MAPK) signaling pathway, phosphatidylinositol-3-kinase (PI3K) pathway, G-protein-coupled receptor (GPCR) family, and epithelial-to-mesenchymal transition [40,46]. Here, WNK2 is linked to melanoma.