A novel BRAF mutation (an aminoacidic insertion in codon 599) was identified in a melanoma patient in the P-loop activating site, mutation that was not discovered before in melanoma, but was detected rarely in Papillary Thyroid Carcinoma and Anaplastic Thyroid Carcinoma, which highlights the heterogeneity of this disease [54]. This evidence concerns the gene BRAF and melanoma.