Some studies assert the idea that melanoma development is accompanied by an epithelial-to-mesenchymal (EMT) switch characterized by the melanocytes loss of E-cadherin expression and acquisition of some mesenchymal markers as SNAIL (transcription factor of zinc-finger family), SLUG (transcriptional repressor of E-cadherin), TWIST (Twist-related protein 1), and ZEB1 (Zinc finger E-box binding homeobox 1 transcription factor) [32,41]. Here, TWIST1 is linked to melanoma.