A relevant model of melanoma was considered to be the one initiated in neonatal transgenic for hepatocyte growth factor/scatter factor (HGF/SF) mice (after a single neonatal dose of mild erythemal UVB radiation), that presents melanocytes localized in the epidermis and the tumor arose in different phases similar with the ones described for human melanoma: benign nevus, radial growth phase, vertical growth phase, and late metastatic spread to other organs [58,80]. This evidence concerns the gene HGF and melanoma.