CDK4 and neoplasm: Based on the genetic assessment of a tumor biopsy taken at progression of disease (PD) patients will receive either an inhibitor of cyclin-dependent kinases CDK4/6 (ribociclib, LEE011), of class I PI3K (buparlisib, BKM120), of the c-MET receptor tyrosine kinase (capmatinib, INC280), or of fibroblast growth factor receptor (FGFR) kinase (BGJ398) in a triple therapy approach (NCT02159066).