Based on the enhanced sensitivity of tumor cells with inactivated tumor suppressor genes BRCA 1 and 2 towards PARP-1 inhibition [37], the PARP inhibitors olaparib, rucaparib, and niraparib could recently receive FDA approval for the treatment of BRCA-mutant ovarian and refractory breast cancers. The gene discussed is PARP1; the disease is breast carcinoma.