In melanoma, due to variable expression of TRAIL-R1/DR4, TRAIL-R2/DR5, and other DRs, the choice and specificity of the agonistic antibody as well as its ability to crosslink Fcγ receptors on myeloid cells turned out to be crucial for effective induction of apoptosis signaling and therapeutic efficacy [25]. Here, TNFRSF10B is linked to melanoma.