In lung tissues, treatments with antrodan only (20 mg/kg and 40 mg/kg), and cisplatin only (1 mg/kg) significantly reduced protein expression of MMP-2, with reductions of 38.3% (p < 0.05), 49.9% (p < 0.05), and 48.1% (p < 0.05), respectively, when compared with the tumor control group (Figure 4). Here, MMP2 is linked to neoplasm.