However, in other studies, obesity was not found to be a risk factor for perioperative thromboembolic events in patients undergoing THA or TKA.[32–35] In our study, we showed that leptin levels were associated with BMI, but the BMI itself was not a predictor of postoperative DVT, and the predictive value of leptin was independent of BMI values. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.