Transient receptor potential (TRP) channels have been implicated in the generation (TRPV1, TRPV4, TRPA1)[19] and inhibition (TRPM8) of visceral pain signals in IBS.[20] TRPV1 of IBS patients has been shown to be more sensitive compared to that of healthy volunteers. This evidence concerns the gene TRPV1 and irritable bowel syndrome.