TXA's efficacy in preventing fibrin-clot degradation, as well as its 90% renal elimination within 24 hours, makes it a prime candidate for use in TJA procedures.[62] In the first hours of surgery, there is an enhanced release of tissue plasminogen factor (t-PA) that remains elevated for up to 24 hours, contributing to increased fibrinolytic activity and, in turn, postoperative anemia. Here, PLAT is linked to anemia.