Expression of CD30 has been demonstrated in non-lymphoid and lymphoid neoplasms, like Hodgkin lymphoma.[6] A recent work has demonstrated that CD30 is frequently expressed in the aggressive form of mastocytosis raising the hypothesis of a specific association.[7–10] However, the study by Morgado et al[11] using flow cytometry analysis showed that CD30 expression in bone marrow MCs was detected in both aggressive and indolent disease. Here, TNFRSF8 is linked to mastocytosis.