Protein kinase A catalytic alpha subunit is a disease driver in 30–40% of cortisol-producing adenoma (CPA) and was associated with reduced DNA methylation at the CYP11B1 promoter that may result in CYP11B1 transcription and hypercortisolemia (Kometani et al. 2017). The gene discussed is CYP11B1; the disease is adrenal gland hyperfunction.