B2M and neoplasm: We then analyzed the mRNA data from TCGA, no difference of the expression of other immune related genes including B2M, CD274, CD8A, CTLA-4, CXCL10, CXCL11 and several chemokines was detected between two groups (Fig. 2d) except that the mRNA expression of FAS was lower in TP53 mutation than TP53 wild-type patients (FDR < 0.05, Fig. 2e) It has been demonstrated that TP53 may up-regulate FAS expression in tumor cells, which results in the induction of CTL-mediated apoptosis [11,12].