GRN and Atrophy: Previous studies have shown that each mutation has a distinct pattern of atrophy: Mutations in MAPT have been associated with atrophy predominantly in the anteromedial temporal lobes [6, 7], whereas mutations in GRN are associated with an asymmetric pattern of atrophy that involves the frontal, temporal and parietal lobes [6, 8]; C9ORF72 mutation carriers have relatively widespread cortical atrophy, including posterior areas [1, 9, 10].