After controlling for age, sex, years of education, SES, smoking, alcohol intake, presence of hypertension, stroke history, GDS-K, CIRS, presence of APOE e4 allele, and amount of ginseng intake during 4 years in the repeated-measures ANCOVA model, there was no group effect for CERAD total score and MMSE score (F = 1.060, df = 2.0, p = 0.346 for CERAD total score; F = 0.220, df = 2.0, p = 0.800 for MMSE). Here, APOE is linked to Hypertension.