There was a significant effect of cumulative ginseng intake on CERAD total score after controlling for covariates, including age, sex, years of education, SES, smoking, alcohol intake, presence of hypertension, stroke history, GDS-K, CIRS, and presence of the APOE e4 allele (F(2, 4762) = 3.978, p = 0.019). The gene discussed is APOE; the disease is hypertensive disorder.