AQP4 and Hypoglycemia: However, hypoglycemia induced significant increases in the extravasation of EB, and AQP4 deletion significantly decreased EB leakage (2.67 ± 0.28 vs. 3.51 ± 0.38 μg/g brain weight, p < 0.01), suggesting that AQP4 preserved the alteration of BBB permeability under acute hypoglycemic conditions.