CK1α phosphorylates pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) at Ser1359, Thr1363, Ser1379, and Ser1381 leading to its ubiquitination and degradation, which may promote colon cancer progression [166]. The gene discussed is CSNK1A1; the disease is colonic neoplasm.