Activated B cell-like subtype of diffuse large B-cell lymphoma (ABC DLBCL) cells require CK1α for constitutive NF-κB activity [11, 88]; additionally, the oncoprotein Y box-binding protein 1 is phosphorylated by CK1α at Ser176, resulting in NF-κB activation [89]. Here, CSNK1A1 is linked to diffuse large B-cell lymphoma.