It stabilizes phosphatase and tensin homolog deleted on chromosome ten (PTEN) by abrogating PTEN phosphorylation and antagonizing neural precursor cell expressed, developmentally down-regulated 4-1 (NEDD4-1) induced PTEN polyubiquitination, which suppresses NSCLC cell growth [81]. This evidence concerns the gene PTEN and non-small cell lung carcinoma.