CK1α phosphorylates type I interferon receptor 1 (IFNAR1) at Ser535 and thereby induces its ubiquitination and degradation via recruitment of β-TrCP E3 ubiquitin ligase in response to endoplasmic reticulum stress as well as infection [137, 138] by the protozoan Leishmania major or vesicular stomatitis virus (VSV) in human cells [137] and by infectious bursal disease virus in chicken [139]. This evidence concerns the gene IFNAR1 and infection.