CBS and neoplasm: Although in our patients the size of tumors increased by a grade (grade I – 3.5 ± 1.47 cm, n = 2; grade 2–6.2 ± 0.95 cm, n = 9; grade IV – 9.25 ± 0.73 cm, n = 3), immunohistochemical staining with anti-CBS antibody suggested a rapid decrease due to an increased grade of tumor (Fig. 2).