As our prior evaluations on B4GALT1 in leukemia [15], hepatocellular cancer [13], and renal cancer [18] indicated its pivotal part in cancer biology, we used IHC to analyze B4GALT1 expression in MIBC clinical samples and to determine its connection to clinicopathological features and patients’ overall survival (OS). The gene discussed is B4GALT1; the disease is hepatocellular carcinoma.