CD274 and neoplasm: As glycans regulate immune response interfering with tumor surveillance [26], we explored whether the B4GALT1 expression was associated with PD-L1 and CTLA4, whose humanized antibodies have shown unprecedented clinical results in patients with MIBC, and both had positive spearman correlation, indicating that tumor cell of high expression B4GALT1 could form more potent immunosuppressive microenvironment.