ESR1 and cancer: Positive KIBRA nuclear expression (KIBRAN) (score 2 or 3) was significantly associated with low recurrence rate (p = 0.014), low lymph node stage (0 or 1) (p = 0.006), positive ER expression (p < 0.001), positive PgR expression (p < 0.001) and Ki67 positivity in ≥14% of cancer cells (p < 0.001).