Specifically, we performed gene set analysis on published resistance signatures [38, 41], transcription factors previously associated with the EGFR signaling network during cetuximab response in HNSCC [39, 41], and canonical pathways from MSigDB [37, 45] (Additional file 1: Figure S6; Additional file 3: Table S2). The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.