The activation of CB1 or CB2 within the ECS leads to the activation of corresponding signaling pathways involved in tumor processes, including the PI3K/Akt pathway, the regulation of adenylyl cyclase, the cyclic AMP-protein kinase-A (cAMP-dependent PKA) pathway, ERK (extracellular signal-regulated kinase) and MAPK (mitogen-activated protein kinase) [12, 14]. This evidence concerns the gene CNR2 and neoplasm.