CDCP1 increases the migration and invasiveness of cancer cells and anchorage-independent cell survival [15, 16] through its interaction with important signalling pathways in tumor aggressiveness, such as Akt [11], PKCδ [17], Src [12, 14, 16, 18–20], and Extracellular signal-regulated kinases 1–2 (ERK1/2) [21]. This evidence concerns the gene MAPK3 and cancer.