However, after adjustment for age, sex, diabetes mellitus, BSA, PD vintage, history glucose exposure, nPCR and RRF, serum IL-6 [β = 0.048 (0.019–0.077), P = 0.001] and serum Ang-1 [β = − 0.068 (− 0.127,-0.010), P = 0.003] were independently associated with Prcl. This evidence concerns the gene IL6 and diabetes mellitus.