After adjustment for age, sex, diabetes mellitus, BSA, PD vintage, history glucose exposure, nPCR and RRF, serum IL-6 [β = 0.105 (0.011–0.197), P = 0.028] and serum Ang-1 [β = − 0.122 (− 0.217– -0.026), P = 0.012] were independently associated with MTACcr in the Model2; dialysate IL-6 AR [β = 0.130 (0.061–0.199), P = 0.01] and dialysate Ang-1 AR [β = − 0.082 (− 0.157– -0.007), P = 0.032] were independently associated with MTACcr in the Model3 (Table 4). Here, IL6 is linked to diabetes mellitus.