Generation of stem cell-derived neurons with robust NMDAR-mediated synaptic transmission would have specific translational value, as variants in and around the glutamate ionotropic receptor NMDA type subunits 2A and 2B (GRIN2A and GRIN2B) have been implicated in epilepsy, intellectual disability, autism, and schizophrenia (Schizophrenia Working Group of the Psychiatric Genomics Consortium, 2014; Epi, 2015; Sanders et al., 2015). Here, GRIN2B is linked to schizophrenia.