CD40LG and periodontitis: ,22 Mouse B cell was one of the first definite cell types which has been proved to directly respond to immunostimulatory CpG-containing DNA sequences in vitro and in vivo.12,17 Our recent study has also suggested that local administration of CpG plus CD40L can induce B cell IL-10 competency thus decreasing inflammation and bone loss in ligature-induced experimental periodontitis in WT mice.29