Recently it has been proposed that in the early phase of Burkholderia infection caspase-11 may act as an IFNγ-inducible effector mechanism because of its reliance on the IL-18-IFNγ axis for priming, which would place non canonical inflammasome downstream of canonical caspase-1 activation [15]. The gene discussed is IL18; the disease is Burkholderia Infections.